Polynucleotides
Treatment

We now offer an advanced range of polynucleotide-based injectables, as the next step in regenerative medicine – Plinest, Plinest Eye, and Newest. Formulated with highly purified polynucleotides HPT®, derived from trout DNA, these treatments offer cellularlevel rejuvenation through enhanced skin collagen and elastin production. Winner of Aesthetics Awards “Best New Product” 2024, they combine science-backed effectiveness with minimal downtime.

Healthcare professional administering injection to patient's neck

Watch the Polynucleotides Treatments in Action

Target Areas & Benefits

Plinest

Target Areas:
Face, neck, décolleté, body

Benefits

  • Promotes fibroblast activity, boosting collagen, elastin, and hydration
  • Improves skin elasticity, texture, firmness, and moisture retention
  • Helps reduce fine lines, acne scars, pigmentation, and photo-aging
Plinest polynucleotides injection product box by Mastelli
Plinest Eye polynucleotides cosmetic product packaging box

Plinest Eye

Target Areas:
Delicate skin around eyes and brows

Benefits

  • Addresses under-eye dark circles, puffiness, and fine lines
  • Enhances firmness and elasticity in area around the eye
  • Delivers cellular repair and collagen biostimulation

Newest

Target Areas:
Mature or dehydrated skin on face, neck, body, scars, stretch marks

Composition: Polynucleotides HPT® + Hyaluronic Acid + Mannitol

Benefits

  • Deep hydration and improved skin turgor
  • Strengthens skin matrix and elasticity in mature tissue
  • Effective on scarred, sun-damaged, or dehydrated skin
Newest aesthetic product box with hyaluronic acid and polynucleotides

Are you ready to book your Polynucleotides treatment?

Experience advanced skin regeneration with minimal downtime – book your Polynucleotides treatment today and rejuvenate confidently.

Frequently Asked Questions 

We aim to answer all your questions before your treatment.  If you have any further questions, please do not hesitate to contact us or book a consultation to discuss your personalised treatment.
What are Polynucleotides?

Polynucleotides are naturally occurring molecules that stimulate cell repair, boost collagen and elastin production, and deeply hydrate the skin for improved texture and firmness.

Which concerns can they treat?

They target fine lines, wrinkles, acne scars, pigmentation, under-eye puffiness, dark circles, and dehydration, and can also improve skin elasticity and overall tone.

How many sessions will I need?

Most clients benefit from a course of 2–4 treatments spaced a few weeks apart. Your plan will be personalised during consultation.

Is there downtime?

Downtime is minimal, with possible mild redness, swelling, or bruising at injection sites, usually resolving within 24–48 hours.

How long do results last?

Results typically last several months, with maintenance sessions recommended to prolong the benefits.

Is the treatment safe?

Yes. Polynucleotides are biocompatible and well-tolerated, with all treatments performed by trained professionals following strict safety protocols.

View our latest news stories:

Profhilo in Lancashire: What It Is and What to Expect

Profhilo in Lancashire: What It Is and What to Expect

If your skin has started to look a little less firm or a little more tired than it used to, you've probably come across Profhilo. It's talked about a lot, and often misunderstood. Profhilo isn't a filler and it isn't a wrinkle-relaxing injection. It sits in its own...

read more
Lip Augmentation: Achieving Natural, Balanced Results

Lip Augmentation: Achieving Natural, Balanced Results

Lip augmentation has become one of the most requested non-surgical aesthetic treatments for individuals seeking subtle enhancement rather than dramatic change. Modern techniques focus on creating natural-looking volume, improved symmetry, and balanced facial...

read more

Book Your treatment with one of our friendly team