Polynucleotides are a group of injectable treatments used in regenerative aesthetics, and if you are looking into polynucleotides in Lancashire the practical answer is this: they are a prescription-led, clinician-assessed treatment, usually given as a short course of appointments a few weeks apart, and whether they are appropriate for you can only be established at a face to face assessment. At RejuvaMed, our doctor-led clinic in Clitheroe, that assessment is the starting point for every plan, and our clinician will advise you on what is and is not suitable for your skin.
This guide covers what the treatment involves, how an appointment tends to run, how polynucleotides sit alongside other injectable skin treatments, and the questions worth asking any clinic before you book.
What are polynucleotides?
Polynucleotides are injectable products used in the skin. They are not dermal fillers, and they are not intended to add volume or reshape a feature.
The polynucleotide range used in clinic includes products formulated for the face, for the delicate skin around the eyes and for intimate health, which is why the treatment comes up in conversations about several different concerns rather than just one. You can see the range we hold on our polynucleotides treatment page.
Because these are prescription-only products in the UK, they must be prescribed by an appropriately qualified prescriber following a consultation. That is not a formality. It is the point at which your medical history, any medication you take and your expectations all get looked at properly.
What happens at a polynucleotide appointment?
Every clinic works slightly differently, but a well-run appointment usually follows a recognisable pattern.
Consultation and assessment. A clinician reviews your medical history, looks at your skin in person and talks through what you are hoping for. This is where suitability is decided, and where you should expect an honest answer if the treatment is not right for you.
Planning. If the treatment is appropriate, your clinician explains the plan: how many appointments are typically involved, how far apart they sit and what the aftercare looks like. Numbers vary by person and by area treated, so the figures that matter are the ones you are given in person.
Treatment. The product is injected into the skin using very fine needles across a series of small injection points. A topical numbing cream can be used for comfort. Appointments are short.
Aftercare. You will be given specific aftercare instructions covering things like sun exposure, make-up, exercise and skincare in the days afterwards. Your clinician will talk you through what to expect at the injection points and what to do if you have any concerns.
Review. Because the treatment is delivered as a course, there is a natural review point at each subsequent appointment.
Polynucleotides, Profhilo and skin boosters: how the conversation usually goes
Patients often arrive having read about several injectable skin treatments and want to know which one they should be asking for. The more useful framing is that these are different tools, and the choice is a clinical judgement rather than a shopping decision.
Broadly, the conversation in clinic tends to separate them like this:
- Polynucleotides are discussed in the context of skin quality and the skin’s own repair processes.
- Profhilo is a bio remodelling treatment, discussed where firmness and overall skin quality across a whole area are the concern.
- Dermal fillers are structural, and are discussed where volume or contour is the concern.
Any of them can be inappropriate for a given person, and sometimes the right recommendation is none of the above, or a skincare and lifestyle plan first. Our clinician will advise which route fits your assessment. You can see the full range on our facial treatments pages.
Choosing a clinic for polynucleotides in Lancashire
The single most useful thing you can do before booking any injectable treatment is establish who is treating you and under what oversight.
That is not simply good sense, it is the direction regulation is heading. The Health and Care Act 2022 gave the Government the power to introduce a licensing scheme for non-surgical cosmetic procedures in England, and the Government’s response to its consultation was published in August 2025, setting out a risk-based model in which higher-risk injectable procedures require oversight from a regulated healthcare professional (House of Commons Library: the regulation of non-surgical cosmetic procedures in England, Health and Care Act 2022, section 180). No licensing scheme is in force yet, so for now the responsibility sits with you to ask.
Sensible questions:
- Who performs the treatment, and what are their professional qualifications and registration?
- Who prescribes the product, and did they assess me in person?
- What happens if I have a concern afterwards, and who do I contact?
- Is the clinic regulated for the medical services it provides?
RejuvaMed is a doctor-led clinic in Clitheroe with a multi-disciplinary medical team, and it is an easy trip from Preston, Blackburn, Burnley and across the Ribble Valley. We are happy to answer all four of those questions before you commit to anything.
FAQ
Are polynucleotides the same as dermal fillers?
No. Dermal fillers are used to add volume or change contour. Polynucleotides are a different category of injectable and are not used for volume. Your clinician will explain which is relevant to your assessment.
How many appointments are involved?
Polynucleotides are usually delivered as a short course rather than a single session, with appointments spaced a few weeks apart. The number that applies to you is confirmed at your consultation.
Do polynucleotide injections hurt?
Very fine needles are used and a topical numbing cream can be applied beforehand for comfort. Most people describe the appointment as quick and manageable.
Is there any downtime?
Aftercare advice is given at your appointment and typically covers sun exposure, make-up and exercise for a short period. Your clinician will explain what to expect and how to look after the area afterwards.
Can anyone have this treatment?
No. It is a prescription-led treatment and suitability depends on your medical history and assessment. Our clinician will advise, and will tell you if it is not appropriate for you.
Next step: book a consultation in Clitheroe
If you have been researching polynucleotides in Lancashire, the useful next step is not more reading, it is an assessment. At RejuvaMed every plan begins with a proper consultation with a qualified clinician, an honest conversation about whether the treatment fits, and a clear explanation of what is involved. We would be glad to help you work out where to start.
